Resting State Functional Connectivity and Thrombolysis Mediated Reperfusion in Acute Ischemic Stroke: A Pilot Study

نویسندگان

  • Priyantha Herath
  • Taylor Hanayik
  • Kaitlin Krebs
  • Lauren Dennis
  • Christopher Rorden
  • Julius Fridriksson
  • Souvik Sen
چکیده

Introduction: Intravenous Tissue Plasminogen Activator (rTPA) is used to treat acute ischemic stroke (AIS). Early recanalization from this leads to better stroke outcomes, but the exact mechanism remains unknown. To clarify this, we correlated tissue perfusion and functional outcomes in acute stroke patients (AIS) who received rTPA to resting state default mode network (DMN) and task-positive (TPN) activities measured with fMRI. Following NIH stroke scale (NIHSS) assessments, patients underwent magnetic resonance imaging (MRI) scans during rTPA infusion (baseline), six hours post stroke and at 30d follow up visit.

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تاریخ انتشار 2015